We Are the Wrong Animal for the Stars
The Tsiolkovsky equation tells you how to leave Earth. It tells you what mass ratio you need, how much delta-v you can extract from a given propellant, how fast you can plausibly go. It does not tell you what to do with your crew on the third decade of a thousand-year trip, when the youngest person aboard has never seen a sky and the oldest has forgotten what one looks like. ...